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Both drug labels now include ileus, a condition where normal intestinal muscle contractions stop entirely, as a potential adverse event

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A precursor to MT-II, MT-I is a linear tridecapeptide that acts primarily on MC1R to elicit tanning effects, among other distinct functions

Additional strategies under investigation aim to develop small-molecule GLP-1R modulators, sustained-release depot formulations, and combination regimens that pair GLP-1R agonists with complementary agents to maximise metabolic and organ-protective benefits